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Treatment With Hydrochlorothiazide And Alendronate In Patients With Stones And Bone Mineral Density Loss. Evolution Of Bone Metabolism And Calciuria With Medical Treatment.
Autor: M. Arrabal-martín, S. González-torres, M.c. Cano-garcía, A. Poyatos-andújar, F. Abad- Menor, M.a. Arrabal-polo.
Editorial: Archivos Españoles de Urología
9 páginas
Pago único: €14.88
Requiere suscripción: Académico
Tipo de publicación: Articulo
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OBJECTIVES: Treatment of calcium

stones is based on diet and pharmacological measures

such as the use of thiazides and other drugs. The aim

of this study is to assess the effect of alendronate on

hydrochlorothiazide on urinary calcium and bone

mineral density in patients with calcium stones.

METHODS: Prospective observational study involving

77 patients with relapsing calcium stones divided into

2 groups according to treatment received. Group 1: 36

patients treated with alendronate 70 mg/week;

Group 2: 41 patients treated with hydrochlorothiazide

50 mg/day. All patients receive diet recommendations

and fluid intake. Studied and analyzed among other

variables were bone mineral density, bone turnover

markers and calciuria before and after 2 years of

treatment. Statistical study with SPSS 17.0, statistical

significance p<0.05.

RESULTS: No statistically significant differences in

the distribution by sex or age of the patients between

groups. In group 1 statistically a significant decrease

was observed in the b-crosslaps and improvement in

bone mineral density, along with decreased urinary

calcium after 2 years of treatment. In Group 2 statistically

significant decrease in urinary calcium and fasting

calcium/creatinine was seen, along with improvement in

bone mineral density after 2 years of treatment. In group 1,

there is a more obvious and significant improvement in

bone mineral density compared to 2 and b-crosslaps

decrease. However, in group 2 the decrease in urinary

calcium and calcium/creatinine was more significant

than in group 1.

CONCLUSION: Treatment with thiazide decrease

calciuria and produces an improvement in bone mineral

density, although not in the same range as treatment with


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Revista Internacional de Urología indexada y peer-reviewed, fundada en 1944, dirigida a toda la comunidad científica. Aquí encontrarás las últimas novedades y hallazgos urológicos. Publicamos 10 números anuales.